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What Are the Effects of PRP on Skin Rejuvenation?

Platelet-rich plasma (PRP) injections have attracted the attention of cosmetic dermatologists for use in skin rejuvenation. However, most information regarding the efficacy of PRP is derived from in vitro (in the cultured cells) studies. A recent study sought to determine the in vivo proliferation of dermal collagen. The objective was to investigate the effect of PRP on skin rejuvenation (and changes in collagen) by histological analysis of dermal collagen.

Twenty women ranging in age from 40 to 49 years were enrolled into the study; 60% were Fitzpatrick skin types II, 25% were Fitzpatrick skin types III and 15% were Fitzpatrick skin types I. Using punch biopsies obtained before and after treatment with PRP or saline for control and histological evaluation, researchers compared the collagen of patients with baseline collagen levels and control side. In the PRP side, great improvement from the baseline data was observed in the fourth week after only one treatment. PRP was considered effective, significantly improving collagen. The authors note that there was also an increase in collagen on the control side where the skin was treated with saline. The differences were statistically significant between saline injected side and baseline (untreated) collagen levels. The reason of elevated collagen levels of the saline injected side is from the effect of skin needling.

The authors conclude that PRP increases dermal collagen levels not only by growth factors, but also by skin needling. PRP application could be considered as an effective (even a single application) and safe procedure for facial skin rejuvenation.

 

Byline: Martha L. Sikes, MS, RPh, PA—C

Posted: January 16, 2017

Source: NCBI
Adapted from the original article.

[Image: Shutterstock]




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