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Topical Cyclosporine A is an Effective Treatment for Ocular Rosacea

Rosacea is a chronic skin disorder affecting the sebaceous glands. Characteristic symptoms include facial flushing, redness and telangiectasias, inflammatory papules, and occasionally connective tissue hypertrophy and ocular involvement. Ocular rosacea is more common between the ages of 50 and 60 and may accompany primary skin findings or can appear independently. Ocular signs of rosacea usually involve periorbital lymphedema; eyelid margin erythema and telangiectasia; blepharitis; hordeola and chalasia; dry eye; bacterial colonization; and corneal erosion. Ocular symptoms of rosacea may be out of proportion to the signs and include burning, foreign body sensation, itching, redness, watering, photophobia, pain and lid swelling.

In a recent study published in the International Journal of Ophthalmology, patients with ocular rosacea were treated with either topical cyclosporine A emulsion or oral doxycycline to compare the effects on rosacea-associated ocular changes and dry eye complaints.

The study found that while both drugs were found to be effective on rosacea associated ocular changes, cyclosporine A was more effective in symptomatic relief and in the treatment of eyelid signs than doxycycline. Ocular rosacea is a chronic condition and requires long term treatment; doxycycline has various side effects limiting its long term usage. Currently there is no standard therapy for the treatment of ocular rosacea and the limitations of long-term oral doxycycline use underscore the need for alternative therapies. Cyclosporine A may offer a better option for treatment.

By: Wendy Meltzer, MPH

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458660/

Adapted from the original article.

[Image by: Parg]




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