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Nanoparticles Can Promote Wound Healing

Nanoparticle therapy has decreased the healing time of all sorts of wounds by half. Molecules of silencing RNA (siRNAs) within the tiny gel capsules, of nanoparticles that shut down the enzyme known as fidgeting-like 2 (FL2). FL2 enzymes slow the healing of wounds by restricting skin cells from moving into damaged tissue. With FL2 shut down the skin cells are able to reach wounds and promote healing.

The nanoparticles with their siRNAs were tested topically by applying them to mice with skin excisions or burns. The wounds of the mice healed more than twice as fast as those that were not treated with nanoparticles. Within months testing will be done on pigs, whose skin is more closely comparable to that of human skin. If all goes well, the FDA may approve nanoparticles for humans in the next few years.

This new drug may open up possibilities beyond that of healing wounds such as everyday cuts and burns, surgical incisions and chronic skin ulcers. Pilot studies have been carried out and show that FL2 can be targeted to promote the regeneration of heart tissue after a myocardial infarction and neural regeneration with recovery of function after peripheral nerve or spinal cord injury.

Researchers in India looking for a better way to deliver silver nitrate to burns, have developed similar nanoparticle therapy. This therapy showed a decrease in the typical side effects seen with silver nitrate, reduced the risk of infections and quickened healing time.

By: Joleen M. Volz, MPAS, PA-C, SDPA Secretary/Treasurer

[image by ionscope]