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LIVE BLOG: On the Benefits of Naftin Cream [Product Theater: Merz]

In this Live Blog, Dr. Leon Kircik lectures on the benefits of Naftin cream.  NAFTIN (naftifine hydrochloride) Cream, 2% is for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum.  It is indicated for adult patients ≥ 18 years of age.  The highlight of Naftin is in the finding that the drug continues to work after treatments have stopped.

 

Clinical overview: Naftin Cream 2%

Two blind, renadomized, vehicle–controlled phase 3 trials

Once a day for two weeks (higher treatment adherence)

 

Helpful ingredients

Benzyl alcohol: Stays on the skin

Isopropyl myristate: Goes through the stratum corneum

 

For treatment of Tinea Cruris

When looking at the results for “Complete Cure” once must look at the definition for this study.  It is defined as negative fungal culture, and negative KoH.  Moreover, “Clinical Cure” must score 0 for a high success rate, meaning a complete cure of saling, erytheme, and pruitus.

(Difficult to get all of these things to be 0.  Remember this as you look at success rates)

At two weeks of Naftin use, there were positive changes in the skin, although presenting as low due to all the criterium involved.

At 4 weeks, after ending treatment, results began to increase.  At 2 weeks  clinical success was 74% success, 84% at 4 weeks.  Mycological cure increased from 67% to 72%.  This is because the drug stays in the skin and continues to work even after applications have stopped.  The same results were seen for the drug when used for interdigital tinea pedis.

 

 

 

[image by Rich Jacques]




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