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Link Between the Inflammation Response Post Injury and In Regeneration

Recent studies have found new links between the inflammatory response seen after tissue injury and regeneration. This inflammatory response leads to signal pathways that are activated by the receptor protein gp130, which then turns on several transcription factors. The transcription factors involved are responsible for healing and repair of tissue by stimulating regrowth of normal tissue stem cells. These findings may prove to be pivotal in ongoing research of plaque psoriasis and atopic dermatitis. Receptor protein gp130 is influenced by interleukin-6 (IL-6), which is known to be higher in patients in recovering from tissue injury. The IL-6 pathway in psoriasis patients lends itself to hyperactivity, leading to over abundant proliferation of keratinocytes. The Koebner phenomenon is a classic example of tissue injury leading to activation of the gp130 and IL6 cascade. The issue lies in the inability of the psoriatic to turn off the pathway at the appropriate time, leading to development of plaques. Among other pathways, IL-6 is now proving to be a focus of new research in biologic therapy for psoriasis. Conversely, the role of IL-6 in epidermal barrier repair after injury to the skin is critical to recovery from flares of atopic dermatitis. Patients with atopic dermatitis suffer from ongoing disruption of the skin’s barrier function, which lends itself to irritation from exposure to numerous antigens and a vicious itch-scratch cycle. Maintaining the integrity of the skin barrier has long been the mainstay of treatment for eczematous disease. The ability of IL-6 to induce repair of barrier function is a promising prospect in the development of topical management of atopic dermatitis as well. Ongoing research is needed to investigate the myriad of signaling pathways involved in all disease processes and empower us to decrease the burden of these diseases for our patients.

Adapted from original press releases.

By: Jennifer Conner, MPAS, PA-C; SDPA Diplomate; Director at Large

Sources: UCSD News, Nature

[image by Doug Beckers]


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