Modern Setup Host Windows 10
Kroger Feedback


Infants to Elderly, Cloderm is Fine


In this Live Blog from the 2014 SDPA conference in San Diego, Promius Pharma LLC shared about Cloderm cream as a treatment for inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


Cloderm (clocortolone pivalate 0.1%) Cream

Cloderm has been around for a long time (approximately 40 years), and has many uses. There is no age restriction: infants to elderly, Cloderm is fine. It is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

1. Potency: Midstrength class 4 topical steroid.

2. Let’s talk organic chemistry: The Clocortolone pivalate structure is extremely unique in design.

3. There are 5 different types of Allergy groups for topical steroids.

  • Allergy groups are an “under-discussed issue.”
  • e.g. When you have atopic dermatitis the steroids should work. Why don’t they? They patient is likely allergic to the topical steroids. This becomes a problem for diagnosis.


The cream proves to be high in strength and low in adverse effects. The product had no evidence of HPA- Axis and for long-term use, there were no systemic, cumulative or delayed adverse events even when used for 7 months.

Cloderm has emollient ingredients but isn’t greasy and the vehicle in Cloderm has no propylene glycole (which is very common, but very allergenic). It is also fragrance and lanolin free! Avoiding the allergens means Cloderm can be classified as a Class C, the only class that has none to low allergenicity. The only two steroids in this class are: Clocortolone Pivalate (Cloderm) & Desoximetasone 

Why is this the case?  The unique design of the clocortolone pivalate.

Ingredients: the vehicle is very important, because it makes or breaks the molecule.


Dosing options are available in a 90g tube, 75 g pump (helpful for amounts for children) and 45g tube.


Patient Case Report with Cloderm Cream

The patient was directed to apply cream to affected areas.  At one week marked improvement of symptoms was seen. Pruritis had decreased from a score of 10/10 irritation to a score of 2 out of 10 and patient reported high satisfaction with therapy. Restoration of the skin barrier was achieved.


Allergenicity Classification: 5 Groups

A – Higher Allergenicity

B – Higher Allergenicity

D1 – Lower Allergenicity

D2 – Higher Allergenicity


Cloderm Cream Clinical Trials

  • These are ancient studies, because this has been around for so long.
  • Early onset action, Day 4, shows patient doing well.


Important Safety Information

  • The most common adverse events with Cloderm Cream include burning, itching, irritation, dryness, and folliculitis
  • Cloderm Cream is contraindicated in patients who are hypersensitive to any of the ingredients
  • As with all topical corticosteroids, systemic absorption can produce reversible HPA-axis suppression
  • No age restriction on use


Image: #000000

Our Sponsors