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Effects of Vitamin D Levels on House Dust Mite Allergies

While the exact role vitamin D plays is not yet known, more information is emerging about the relationship between vitamin D and allergic diseases, including atopic dermatitis (AD). Some studies have shown that vitamin D level can influence the course of immune-mediated disorders.

When it comes to skin diseases, the data has been conflicting. Some studies demonstrated an inverse association between vitamin D levels and AD severity, others showed no significant correlation between vitamin D levels and AD severity. In a recent study, authors hypothesized that vitamin D deficiency might impair immune defense against common allergens such as house dust mite (HDM). The authors aimed to evaluate the correlation between serum vitamin D levels and HDM sensitization according to AD severity.

Using a retrospective case study design, authors looked at 80 patients with AD (either mild to moderate or severe), their serum levels of vitamin D, and associated HDM sensitization. The results showed that in this study, serum vitamin D levels were not correlated with AD severity. Despite previous studies that had shown a correlation between AD severity and HDM sensitization, in this study only patients with severe AD showed high HDM sensitization.

The authors conclude that the results demonstrate that low vitamin D levels may be relevant to high HDM sensitization in severe AD patients. They state that further investigation regarding the effect of vitamin D in HDM sensitization maybe helpful for developing new strategies for the prevention and treatment of AD, but more research is needed to determine the relationship between serum vitamin D levels and HDM sensitization in AD.


Byline: Martha L. Sikes, MS, RPh, PA-C

Posted: September 6, 2017

Source: Synapse Annals of Dermatology
Adapted from the original article.

[Image: Shutterstock]

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