In Atopic Dermatitis, looks can be deceiving. Discover the inflammation beneath.

In Atopic Dermatitis, looks can be deceiving. Discover the inflammation beneath.

Atopic Dermatitis Exposed

 

Current evidence suggests that nonlesional skin is not normal skin because of persistent underlying inflammation throughout the body.1-4 In fact, this persistent underlying inflammation is a source of lesions and itch, the primary signs and symptoms of atopic dermatitis.2-4 The Th2 cytokines IL-4 and IL-13 are key drivers of the underlying inflammatory process.2

 

Watch these videos to learn more about the emerging science in atopic dermatitis.

[Click the thumbnails below to view the videos.]

 

Video #1: In atopic dermatitis, nonlesional skin is not normal skin

Sanofi Video #1: Dr. Lisa Beck

 

Video #2: Genetic signature of nonlesional skin is similar to lesional skin in atopic dermatitis

Sanofi Video #2: Dr. Emma Guttman-Yassky

 

Video #3: IL-4 and IL-13, key Th2 cytokines, drive immune dysregulation in atopic dermatitis

Sanofi Video #3

 

Video #4: Atopic dermatitis is driven by persistent immune dysregulation

Sanofi Video #4: Dr. Mark Boguniewicz

 

Video #5: What is driving atopic dermatitis: the “inside-out” or “outside-in” model?

Sanofi Video #5

 

Video #6: Similarities and differences between atopic dermatitis and psoriasis

Sanofi Video #6

 

Learn more at www.atopicdermatitisexposed.com

 

Sponsored Content: This educational program has been developed by Regeneron Pharmaceuticals and Sanofi Genzyme.

 

References:
1.
De Benedetto A, Rafaels NM, McGirt LY, et al. Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol. 2011;127(3):773-786. 2. Gittler JK, Shemer A, Suárez-Fariñas M, et al. Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. J Allergy Clin Immunol. 2012;130(6):1344-1354. 3. Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004;113(5):651-657. 4. Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.

 

US.DUP.16.10.036

US-ILF-13474

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