Atopic Dermatitis Exposed | Video #6: Similarities and differences between atopic dermatitis and psoriasis

Atopic Dermatitis Exposed | Video #6: Similarities and differences between atopic dermatitis and psoriasis

 

“Is the nonlesional skin in psoriasis also abnormal like it is in atopic dermatitis? And is atopic dermatitis also a systemic inflammatory disease like we think psoriasis is?” Lisa Beck, MD, and Emma Guttman-Yassky, MD, PhD, discuss the similarities and differences between atopic dermatitis and psoriasis.

Dr Beck is a professor of dermatology and the director of translational research at the University of Rochester Medical Center Department of Dermatology and Medicine in Rochester, New York. Dr Guttman-Yassky is an associate professor of dermatology and immunology at the Icahn School of Medicine at Mount Sinai Hospital in New York and director of the Center for Excellence in Eczema, the Occupational/Contact Dermatitis Clinic, and the Laboratory of Inflammatory Skin Diseases.

CLICK HERE | Learn more about chronic inflammation in atopic dermatitis.

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References:
Guttman-Yassky E, Nograles KE, Krueger JG. Contrasting pathogenesis of atopic dermatitis and psoriasis–part I: clinical and pathologic concepts. J Allergy Clin Immunol. 2011;127(5):1110-1118.

Noda S, Krueger JG, Guttman-Yassky E. The translational revolution and use of biologics in patients with inflammatory skin diseases. J Allergy Clin Immunol. 2015;135(2):324-336.

Gandhi NA, Bennett BL, Graham NM, et al. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016 Jan;15(1):35-50.

Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.

Gudjonsson JE, Ding J, Li X, Nair RP, et al. Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J Invest Dermatol. 2009 Dec;129(12):2795-2804.

Guttman-Yassky E, Dhingra N, Leung DY. New era of biologic therapeutics in atopic dermatitis. Expert Opin Biol Ther. 2013 Apr;13(4):549-561.

 

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