Atopic Dermatitis Exposed | Video #2: Genetic signature of nonlesional skin is similar to lesional skin in atopic dermatitis

Atopic Dermatitis Exposed | Video #2: Genetic signature of nonlesional skin is similar to lesional skin in atopic dermatitis

 

“Global gene expression reveals new information. Over this much larger gene set that can be depicted here, we see a strikingly similar pattern of gene expression in lesional and nonlesional skin from atopic dermatitis patients.” In this video, Emma Guttman-Yassky, MD, PhD, explains how the genetic signature of atopic dermatitis nonlesional skin is similar to lesional skin.

Dr. Guttman-Yassky is an associate professor of dermatology and immunology at the Icahn School of Medicine at Mount Sinai Hospital in New York and director of the Center for Excellence in Eczema, the Occupational/Contact Dermatitis Clinic, and the Laboratory of Inflammatory Skin Diseases.

CLICK HERE | Learn more about subclinical defects in atopic dermatitis.

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References:
Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities. J Allergy Clin Immunol. 2011;127(4):954-964.

Malajian D, Guttman-Yassky E. New pathogenic and therapeutic paradigms in atopic dermatitis. Cytokine. 2015 Jun;73(2):311-318.

Guttman-Yassky E, Nograles KE, Krueger JG. Contrasting pathogenesis of atopic dermatitis and psoriasis–part I: clinical and pathologic concepts. J Allergy Clin Immunol. 2011;127(5):1110-1118.
Bieber T. Atopic dermatitis. Ann Dermatol. 2010 May;22(2):125-137.

 

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